Zach Braff as Tom Reilly

Amanda Peet as Sofia Kowalski

Jason Bateman as Chip Sanders

Charles Grodin as Bob Kowalski

Mia Farrow as Amelia Kowalski

Lucian Maisel as Wesley

Donal Logue as Don Wollebin

Amy Poehler as Carol Lane

Fred Armisen as Manny

Bob Stephenson as Doug

Yaffit Hallely as Woman

Josh Charles as Forrest Mead

Marin Hinkle as Karen

Yul Vazquez as Paco

Michael Lawson as Busboy

Paul Rudd as Leon

Nick Grodin as Summers

Robert John Burke as Colonel

Romany Malco as Doctor Hakim Oliver

Carole Troll as Nurse

Sarah Jenkins as Nancy

Edmund Lyndeck as Mr. Hordhaus

Amy Adams as Abby March

Caitlin Miller as Lisbeth

Lauren Weedman as Alice

Michael Cumpsty as Jack Connor

Katie Barrett as Executive

John Benjamin Hickey as Wesley's Dad

Declan Patrick Schenck as Baby Oliver (2 Months)

Brayden Julian Schenck as Baby Oliver (2 Months)

Connor Grace as Baby Oliver (6 Months)

Frank Girardeau as Fire Inspector

Ian Hyland as Steve

Tarina Pouncy as Ticket Agent

Cyrus Hernstadt as Kid with Toy Car

Sig Libowitz as Hassidic Guy

Sheila K. Adams as Steve's Mom

Edwin Lopez as Wheelchair Basketball Player #1

Eddie McGee as Wheelchair Basketball Player #2

Shevy Gutierrez as Lower East Sider (uncredited)

Ismaelpeter Casillas Nelson as Kid at Birthday Party (uncredited)

Laurent Vernin as Tom Reilly (voice) (uncredited)