Ron Perlman as Brother Samuel

Thomas Jane as Maj. 'Mitch' Hunter

Devon Aoki as Cpl. Valerie Duval

Sean Pertwee as Capt. Nathan Rooker

Benno Fürmann as Lt. Maximillian von Steiner

John Malkovich as Constantine

Anna Walton as Severian

Tom Wu as Cpl. Juba Kim Wu

Steve Toussaint as Capt. John McGuire

Luis Echegaray as Cpl. Jesus 'El Jesus' de Barrera

Shauna Macdonald as Adelaide

Roger Ashton-Griffiths as Science Monk

Christopher Adamson as Hodge

Jacqueline Chan as Mishima Ambassador (as Jacqui Chan)

Nicholas Ball as Plutocrat

Georgina Berriman as Grace

Georgina Bryce as Dorothy

Richard Buddle as Soldier

Tim Daniel Clark as Lead Mutant

Vyelle Croom as Bartender

Barry McCormick as Capitol Ambassador

Scott Joseph as Corporate Guard

Farhan Khan as Principal Mutant

Andrew Mackay as Science Monk's Assistant

Tatiana Lavrentieva as Refugee (uncredited)

Albert Tang as Japanese General (uncredited)

Pras Michel as Captain Michaels