George Clooney as Everett

John Turturro as Pete Hogwallop

Tim Blake Nelson as Delmar O'Donnell

John Goodman as Big Dan Teague

Holly Hunter as Penny

Chris Thomas King as Tommy Johnson

Charles Durning as Pappy O'Daniel

Del Pentecost as Junior O'Daniel

Michael Badalucco as George Nelson

J.R. Horne as Pappy's Staff

Brian Reddy as Pappy's Staff

Wayne Duvall as Homer Stokes

Ed Gale as The Little Man

Ray McKinnon as Vernon T. Waldrip

Daniel von Bargen as Sheriff Cooley

Royce D. Applegate as Man with Bullhorn

Frank Collison as Wash Hogwallop

Quinn Gasaway as Boy Hogwallop

Lee Weaver as Blind Seer

Millford Fortenberry as Pomade Vendor

Stephen Root as Radio Station Man

John Locke as Mr. French

Gillian Welch as Soggy Bottom Customer

A. Ray Ratliff as Record Store Clerk

Mia Tate as Siren

Musetta Vander as Siren

Christy Taylor as Siren

April Hardcastle as Waitress

Michael W. Finnell as Interrogator

Georgia Rae Rainer as Wharvey Gal

Marianna Breland as Wharvey Gal

Lindsey Miller as Wharvey Gal

Natalie Shedd as Wharvey Gal

John McConnell as Woolworths Manager

Issac Freeman as Gravedigger

Wilson Waters Jr. as Gravedigger

Robert Hamlett as Gravedigger

Willard Cox as Cox Family

Evelyn Cox as Cox Family

Suzanne Cox as Cox Family

Sidney Cox as Cox Family

Buck White as The Whites

Sharon White as The Whites

Cheryl White as The Whites

Ed Snodderly as Village Idiot

David Holt as Village Idiot