John Cameron Mitchell as Hedwig

Miriam Shor as Yitzhak

Stephen Trask as Skszp

Theodore Liscinski as Jacek

Rob Campbell as Krzysztof

Michael Aronov as Schlatko

Andrea Martin as Phyllis Stein

Ben Mayer-Goodman as Hansel - 6 years old

Alberta Watson as Hansel's Mom

Gene Pyrz as Hansel's Dad

Michael Pitt as Tommy Gnosis

Karen Hines as Tommy's Publicist

Max Toulch as Goth Menses Boy

Maurice Dean Wint as Sgt. Luther Robinson

Ermes Blarasin as Fat Man

Sook-Yin Lee as Kwahng-Yi

Maggie Moore as Trailer Park Neighbor

Renate Options as Tranny Hooker

Taylor Abrahamse as Singing Boy (uncredited)

Thérèse DePrez as Laundromat Customer (uncredited)

Mary Krohnert as Rabid Fan (uncredited)

Shane Mackinnon as HedHead (uncredited)

Alan Mandell as Patron at restaurant (uncredited)

Eileen Murphy as Singer (uncredited)

Rosie O'Donnell as Self (uncredited)

Mike Potter as Renate Options Options - 2nd call girl (uncredited)

Michael Stevens as HedHead (uncredited)