Denzel Washington as Dr. Jerome Davenport

Derek Luke as Antwone Fisher

Malcolm David Kelley as Antwone Fisher Age 7

Cory Hodges as Antwone Fisher Age 14

Viola Davis as Eva May

Joy Bryant as Cheryl Smolley

Salli Richardson-Whitfield as Berta Davenport

Leonard Earl Howze as Pork Chop

Kente Scott as Kansas City

Kevin Connolly as Slim

Rainoldo Gooding as Grayson

Novella Nelson as Mrs. Tate

Stephen Snedden as Berkley

Sung Kang as Receptionist

Yolonda Ross as Nadine

James Brolin as The Captain (uncredited)

Jenifer Lewis as Aunt Mary Williams (uncredited)

Charles Robinson as Howard

Earl Billings as Uncle James

Vernee Watson-Johnson as Aunt Annette

De'Angelo Wilson as Jesse

Kim Johnson as Disc Jockey

Leo Nepomuceno as SP #1

Cordell Stokes as Keith - Age 5

Ellis Williams as Reverand Tate (as Ellis E. Williams)

Timothy Reddick as Dwight - Age 8

Jascha Washington as Jesse - Age 8

Margaret Ford-Taylor as Eda

Bob Banks as Horace

Jada S. Louie as Jeannette

Rebecca Morris as Anna

Brandon Biggins as Eddie

Brandon Lewis as Ray

Eddie Baccus as Blind Piano Player

David Fowler as Chief Master-At-Arms

Sean'e La'Dae as Edward

Linda Cevallos as Sexy Woman

O.L. Duke as Uncle Duke

Michelle Davison as Johnny Mae

Fran Dorsey as Owner

Ruth Stehle as Snide Clerk

John Pittman as Another Clerk

Lissy Gulick as Mona

Edward C. Reynolds III as Man

André Patton as Kenny

Rita Pearson as Cashier

Janaya Reynolds as Young Girl #1

Na'tasha Marie Evans as Young Girl #2

Doug Jewell as Spinoza

Lynn E. Charles as Spinoza's Wife

Jason Dixon as Jason

Mary Bradley Marable as Older Lady

Teresa Hoefke as Case Worker

Angela Gillespie-Winborn as Woman in White

Regina Daye Allen as Woman in Dream Sequence (uncredited)

Gary A. Jones as Relative (uncredited)

Tierney Deanne Collins as Young Girl (uncredited)

Eliza Cortez as County Clerk Worker (uncredited)

Ruby Gonzalez as Salsa Dancer (uncredited)