Brittany Murphy as Krista

Toni Collette as Arden

Rose Byrne as Leah

Josh Brolin as Tarlow

James Franco as Derek

Bruce Davison as Leah's Father

Marcia Gay Harden as Melora

Piper Laurie as Arden's Mother

Giovanni Ribisi as Rudy

Mary Steenburgen as Beverley, Leah's Mother

Kerry Washington as Rosetta

Mary Beth Hurt as Ruth

Nick Searcy as Carl

Carla Jimenez as Ashley's Caretaker