Queen Latifah as M'Lynn

Alfre Woodard as Ouiser

Phylicia Rashād as Clairee

Jill Scott as Truvy

Adepero Oduye as Annelle

Dola Rashad as Shelby

Tory Kittles as Jackson

Afemo Omilami as Drum

Lance Gross as Sammy

Anna Colwell as Nurse Pam

Jeff Rose as Dr. Judd

Michael Beasley as Spud

Demetrius Bridges as Jonathan

Tom Key as Owen Jenkins

Liana Loggins as I.C.U. Patient

Karen Beyer as Caterer

Mark Anthony Brooks as Groom's Relative

Deonna Young as Maid of Honor

Jejuan Smith as Wedding (as Smith Jejuan)

James Busler as Wedding / Reception Guest

Rultz Raymond as Church Member

Simone Jameson as Bridesmaid

Christian Higgins as Wedding / Funeral Guest

Joselyn Jones as Church Girl

Veronica Jackson as Girl on second row

Richard A Moore as Husband