Luke Wilson as Anthony Adams

Owen Wilson as Dignan

Robert Musgrave as Bob Mapplethorpe

Lumi Cavazos as Inez

James Caan as Mr. Abe Henry

Andrew Wilson as John "Future Man" Mapplethorpe

Teddy Wilson as Hector Mapplethorpe

Donny Caicedo as Rocky

Ned Dowd as Dr. Nichols

Jenni Tooley as Stacy Sinclair

Shea Fowler as Grace

Kumar Pallana as Kumar

Jim Ponds as Applejack

Haskel Craver as Jackson

Haley Miller as Bernice

Brian Tenenbaum as H. Clay Murchison

Temple Nash as Temple

Darryl Cox as Bookstore Manager

Dipak Pallana as Bookstore Employee

Stephen Dignan as Rob

Julie Mayfield as Wife in Motelroom

Don Phillips, Jr. as Husband in Motelroom

Anna Cifuentes as Carmen

Melinda Renna as Anita

Richard Reyes as Man in Bar

Julio Cesar Cedillo as Man outside Bar

Tak Kubota as Rowboat

Jill Parker-Jones as Motel Manager

Nena Smarz as Maid

Héctor García as Freezer Guy

Daniel R. Padgett as Freezer Guy

Russell Towery as Cop

Ben Loggins as Cop

Linn Mullin as Detective

Antonia Bogdanovich as Girl at Psych Hospital (uncredited)

Amanda Welles as Bob's Date

Jordan Elliott as Little Girl (uncredited)