John Cusack as Mike Fletcher

Jennifer Carpenter as Kelsey Walker

Mae Whitman as Abby Fletcher

Dallas Roberts as Gary Gemeaux

Sonya Walger as Shelley

Michael Trevino as Tad

Ksenia Solo as Emma

Mageina Tovah as Brittany

Katherine Waterston as Lauren

Gary Anthony Williams as Darryl

Cindy Sampson as Crystal

Maxim Roy as Nurse

Glenda Braganza as Nurse

Meghanne Kessels as Chelsea

Paula Jean Hixson as TV Protestor

Vanessa Matsui as Prostitute

Gerardo Lo Dico as Dynamic Entry SWAT Officer (uncredited)

Omari Newton as Cop in Basement

Charles Papasoff as Jerome

Lita Tresierra as Divine

Vincent Messina as Jed