Jean Claude Ricquebourg as Christopher Columbus

José Antonio Lorente as Self - Geneticist / Narrator (voice)

Cristóbal Colón de Carvajal as Self - Descendant / Narrator (voice)

Marcial Castro as Self - Historian

Esther Martín as Self - Journalist

Ainhoa del Castillo as Self - Colón ADN Coordinator

Regis Francisco López as Self - Journalist

Carlos Bayarri as Self - Museo Pickman Curator

Juan Manuel Martín as Self - Edaphology Professor

Rafael Delgado as Self - Edaphology Professor

Vanessa Gómez as Self - Journalist

Alfonso Sanz as Self - Castilian Theory Promoter

Fernando Branco as Self - 1st Portuguese Theory Promoter

José Matos Silva as Self - 2nd Portuguese Theory Promoter

Eduardo Esteban as Self - Galician Theory Promoter

Inmaculada Alemán as Self - Forensic Anthropologist

José Aguiño as Self - Restorer

Gabriel Martorell as Self - Balearic Theory Promoter

José María Ercilla as Self - Agote Theory Promoter

Francesc Albardaner as Self - Jewish Theory Promoter

Cristina Gutiérrez González as Queen Isabel

Ángel González Álvarez as King Fernando

Juan Frías Sanz as Prince of Viana

Santiago Salgado Bellido as Diego Colón - Son

Saúl de Lucas Muñoz as Hernando Colón

Pepe Pereira as Diego Colón - Brother

Cristina Vargas Carracedo as Margalida Colom

Nerea García Martín as Filipa Moniz

Javier García Botello as Young Columbus

Adrián Casado Cuadrado as Child Columbus (Medina)

Martín Martín Hernández as Child Columbus (Palos)

Carlos Fernández Rodríguez as Bartolomé Colón

Rafael Martínez Macías as Juan de la Cosa

José Luis de la Fuente as King of Portugal

Juan José García Galindo as Luis de Santángel

Vidal López Rojo as Duke of Medinaceli

Juan José Domínguez Monge as Francisco de Bobadilla

Laura Cuadrado Conde as Columbus' Mother (Medina)

Francisco Javier Romero as Columbus' Father

Antonio Ortiz García as Priest #1

Santiago Herranz Alberquilla as Priest #2

Juan José Rodríguez as Monk #1

Samuel Belaúnde as Monk #2

Máximo Gallego as Alonso Sánchez de Huelva

Antonio Barrera as Jewish Man

Monserrat Antiñolo as Jewish Woman

Azucena Montalvo as Secretary

Raúl Sandoval as Man on Phone

Lorenzo Milá as Self - Anchorman (archive footage)