Dania Ramirez as Sadie

Jennifer Carpenter as Angela Vidal

Jay Hernandez as Jake

Steve Harris as Scott Percival

Greg Germann as Lawrence

Johnathon Schaech as George Fletcher

Columbus Short as Danny Wilensky

Andrew Fiscella as James McCreedy

Rade Šerbedžija as Yuri Ivanov

Bernard White as Bernard

Elaine Kagan as Wanda Marimon

Marin Hinkle as Kathy

Joey King as Briana

Jermaine Jackson as Nadif

Sharon Ferguson as Jwahir

Denis O'Hare as Randy

Stacy Chbosky as Elise Jackson

Jeannie Epper as Ms. Espinoza

Barry Sigismondi as Bob Orton

Rosine 'Ace' Hatem as Wounded Woman

Christian Svensson as Armed Guard

Scott Donovan as Armed Guard

Michael Potter as Chief of Police

Jane Justice Park as News Reporter

Craig Susser as Hazmat Doctor

Bert Jernigan as Hazmat Guard

Doug Jones as Thin Infected Man

John C. Meier as Rappelling Guard

Troy Gilbert as Rappelling Guard

Shawn Driscoll as Firefighter

Bryan Ross as Firefighter

Robert Hall as Puppeteer

Benjamin Stockham as Infected Child

Michael Hyland as Video Guy

Josh Polizzi as National Guard

Ben Messmer as Griffin

Joe Fria as Anonymous Source (uncredited)