Molly Shannon as Mary Katherine Gallagher

Will Ferrell as Sky Corrigan / Jesus

Elaine Hendrix as Evian

Harland Williams as Slater

Mark McKinney as Father Ritley

Glynis Johns as Grandma

Jason Blicker as Howard

Gerry Bamman as Father John

Emmy Laybourne as Helen

Jennifer Irwin as Maria

Rob Stefaniuk as Thomas

Natalie Radford as Autum

Karyn Dwyer as Summer

Tom Green as Dylan

Chuck Campbell as Owen

Jack Newman as Mr. Feinstein

Donna Hanover as Mrs. Corrigan

Dan Redican as Freaky Freddy

Joan Massiah as Crucifix Nun

Frank Scott as George

Mallory Margel as Little Mary

Deirdre McCloskey as Rosemary Gallagher

David Warrack as Father David

Aidan Kelly as Thornton Gallagher

Jane Moffat as Sister Eileen

Tracy Wright as Sister Anne

Robert Clark as Little Boy Slater

Rick Campanelli as Reporter

Ariel Manson-Wagner as Reporter

Boyd Banks as Weatherman

Sal Scozzari as Special Ed Kid

Christina Gordon as Special Ed Kid

Susie Dias as Special Ed Kid

David Meinke as Special Ed Kid

Tina Campbell as Cheerleader

Christine Nowland as Cheerleader

Carole Mackereth as Cheerleader

Michael McCloskey as Shamus O'Shea

Blake Brooker as Man with Cake

Joanna Bennett as Student (uncredited)

Gabriel Burrafato as Todd (uncredited)

Phil Crowley as Etiquette Record (voice) (uncredited)

Spencer Humm as Choral Singer (uncredited)

Fraser McGregor as Bike Boy (uncredited)

April Morgan as Dancer (uncredited)

Jonathan Gabriel Robbins as Tom, Whose Dad Is Dead (uncredited)

Jason Sehorn as Man in Pink Tutu (uncredited)

Jean Howell as Moira McDaniels