George Clooney as Jack Foley

Jennifer Lopez as Karen Sisco

Ving Rhames as Buddy Bragg

Don Cheadle as Maurice 'Snoopy' Miller

Steve Zahn as Glenn Michaels

Dennis Farina as Marshall Sisco

Catherine Keener as Adele Delisi

Isaiah Washington as Kenneth

Albert Brooks as Richard Ripley

Luis Guzmán as José 'Chino' Chirino

Viola Davis as Moselle

Nancy Allen as Midge

Jim Robinson as Bank Employee

Mike Malone as Bank Customer

Donna Frenzel as Bank Teller

Manny Suárez as Bank Cop

Keith Hudson as Bank Cop

Paul Soileau as Lulu

Scott Allen as Pup

Susan Hatfield as Parking Lot Woman

Brad Martin as White Boxer

James Black as Himey

Wendell B. Harris Jr. as Daniel Burdon

Chuck Castleberry as Library Guard

Chic Daniel as Shock Lock FBI Man

Keith Loneker as White Boy Bob

Connie Sawyer as Old Elevator Lady

Philip Perlman as Old Elevator Gent

Paul Calderon as Raymond Cruz

Gregory Alpert as Officer Grant

Mark Brown as Ripley Personnel

Sandra Ives as Ripley Receptionist

Joe Hess as Ripley Guard

Betsy Monroe as Waitress

Wayne Pére as Philip

Joe Chrest as Andy

Joe Coyle as Third Ad Guy

Stephen M. Horn as Federal Marshal

Michael Keaton as Ray Nicolette (uncredited)

Samuel L. Jackson as Hejira Henry (uncredited)

Oscar A. Diaz as Airport Patron (uncredited)

Jennifer Dorogi as Waitress (uncredited)

Deborah Smith Ford as Airport Passenger (uncredited)

Mike Gerzevitz as Xenon Light Guard (uncredited)

Thelma Gutiérrez as Flight Attendant (uncredited)

Wayne V. Johnson as Bank Manager (uncredited)

Pati Lauren as Bank Patron (uncredited)

Sherrie Peterson as Shopper (uncredited)

Ronnie Stutes as Gas Station Attendant (uncredited)