Katie Holmes as Samantha Mackenzie

Marc Blucas as James Lansome

Amerie as Mia Thompson

Michael Keaton as President Mackenzie

Margaret Colin as Melanie Mackenzie

Lela Rochon as Liz Pappas

Michael Milhoan as Agent Bock

Dwayne Adway as Agent Dylan

Hollis Hill as Agent Colvin

Ken Moreno as Agent Mercer

Andrew Caple-Shaw as Agent Dryer

Alex Avant as Shift Leader

Barry Livingston as Press Secretary

Piper Cochrane as Communications Director

Adam Donshik as First Lady's Chief of Staff

Damon Whitaker as Charles

Steve Tom as Senator Downer

Peter White as College Dean

Parry Shen as Rally Leader

Johnny Sneed as English Professor

Marilyn McIntyre as Teacher at Party

Ryan Raddatz as Frat Guy #1

Toby Moore as Frat Guy #2

Freddy Bouciegues as Dancing Frat Guy

Austin Priester as Dancing Frat Guy

Scott Hamm Duenas as Frat Guy with Water Gun

Philip Boyd as Frank

Katrina Connor as Sorority Gal #1

Natalie Core as Lady With Camera

Teck Holmes as Mia's Flame

Sophia Chang as Sorority Gal #2

Justine Wachsberger as Passing Student

Andrea Avery as Linda Patterson

Sheila Shaw as Health Center Receptionist

Ann Ryerson as Nurse Practitioner

Andy Umberger as Secret Service Supervisor

Mane Andrew as Mia's Visitor

Jeff Michael as News Reporter

Kent Shocknek as Contentious Reporter

Maria Quiban as White House Reporter #1

Ted Garcia as White House Reporter #2

Tim Liles as Reporter On Street

Dan Brinkle as Caucus Host

Michael Connor as Protester #1

Nicole Avant as Protester #2

Brian A. Smith as Guy In Street

Tore Birkedal as Pizza Guy

Gunther Jensen as Football Coach

Vera Wang as Vera Wang

Joan Rivers as Joan Rivers

Melissa Rivers as Melissa Rivers

Jay Leno as Jay Leno

Forest Whitaker as Narrator (voice)

Sonnet Noel Whitaker as Laughing Girl

Ashlee Gillespie as Awestruck Student (uncredited)

Molly Howe as Grace (uncredited)

Ryan Izay as Student (uncredited)

Chuck Murphy as Potus One (uncredited)

Janet Dey as College Teacher (uncredited)

Bobbi Page as Singer at White House