Meg Ryan as Mary Haines

Annette Bening as Sylvie Fowler

Eva Mendes as Crystal Allen

Debra Messing as Edie Cohen

Jada Pinkett Smith as Alex Fisher

Candice Bergen as Catherine Frazier

Cloris Leachman as Maggie

India Ennenga as Molly Haines

Debi Mazar as Tanya

Bette Midler as Leah Miller

Carrie Fisher as Bailey Smith

Jill Flint as Annie

Joanna Gleason as Barbara

Lynn Whitfield as Glenda Hill

Natasha Alam as Natasha

Ana Gasteyer as Pat

Tilly Scott Pedersen as Uta

Maya Ri Sanchez as Dora

Lindsay Flathers as Taylor

Christy Scott Cashman as Jean

Celeste Oliva as Gilda

Denece Ryland as Cory

Jordan Schechter as Ashley

Marina Re as Helene

Emily Seymour as April Cohen

Allison Seymour as April Cohen

Lauren Lefebvre as May Cohen

Lindsay Lefebvre as May Cohen

Isabella Panteledes as June Cohen

Olivia Panteledes as June Cohen

Madaleine Black as January Cohen

Meredith Black as January Cohen

Ruby Hondros as Jimmy Choo Wearer