Ed Asner as Carl Fredricksen (voice)

Christopher Plummer as Charles F. Muntz (voice)

Jordan Nagai as Russell (voice)

Bob Peterson as Dug / Alpha (voice)

Delroy Lindo as Beta (voice)

Jerome Ranft as Gamma (voice)

John Ratzenberger as Construction Foreman Tom (voice)

David Kaye as Newsreel Announcer (voice)

Elie Docter as Young Ellie (voice)

Jeremy Leary as Young Carl (voice)

Mickie McGowan as Police Officer Edith (voice)

Danny Mann as Construction Worker Steve (voice)

Donald Fullilove as Nurse George (voice)

Jess Harnell as Nurse AJ (voice)

Josh Cooley as Omega (voice)

Pete Docter as Campmaster Strauch (voice)

Mark Andrews as Additional Voices (voice)

Bob Bergen as Additional Voices (voice)

Brenda Chapman as Additional Voices (voice)

Emma Coats as Additional Voices (voice)

John Cygan as Additional Voices (voice)

Paul Eiding as Additional Voices (voice)

Tony Fucile as Additional Voices (voice)

Teresa Ganzel as Additional Voices (voice)

Sherry Lynn as Additional Voices (voice)

Laraine Newman as Additional Voices (voice)

Teddy Newton as Additional Voices (voice)

Jeff Pidgeon as Additional Voices (voice)

Valerie LaPointe as Additional Voices (voice)

Jan Rabson as Additional Voices (voice)

Bob Scott as Additional Voices (voice)