Rachel York as Lucille Ball

Danny Pino as Desi Arnaz

Ann Dowd as DeDe

Madeline Zima as Teen Lucy

LaChanze as Harriett

Olivia Tennet as Lucie Arnaz (uncredited)

Rebecca Hobbs as Vivian Vance

Mervyn Smith as Grandpa Fred

Russell Newman as Bill Frawley

Zoe Carides as Lolita De Acha

Christopher Brougham as Adult Freddy

Ray Woolf as Ed Sedgwick

Peter Mochrie as Don Sharpe

Andrew Robertt as Bob Carroll Jr.

Lauchlin MacDonald as Jess Oppenheimer

Theresa Healey as Madelyn Pugh

Mark Clare as Red Skelton

Vanessa Gray as Carole Lombard

Ian Mune as Buster Keaton

Bartholomew John as Hubbell Robinson

James Bannon as Lucy's Attorney (voice)

Owen Black as Johnny

Laurie Dee as Congressman Jackson

Alex Ewan as Intern

Liddy Holloway as Mildred

Paula Keenan as Sylvia Hahlo

Charles Pierard as Alex Hall

Peter Rowley as Mark Daniels

Joy Watson as Grandmother

Priscilla Bonnet as Young Bette Davis

David Britz as Dancer

Lori Dungey as Italian Grape Crusher

Gregor McLennan as George Mandicos

Daniel Pujol as Doorman

Angela Shirley as Deborah

Olivia Tennet as Lucie Arnaz

Charles Unwin as Clark Gable