Laysla De Oliveira as Tessa

Tom Ellis as Victor Frankenstein

Melissa George as Fiona Hunter

Janet Montgomery as Grace Van Helsing

Tracie Thoms as Mina

Seth Gabel as Roderick Usher

Raza Jaffrey as John Harker

Emma Booth as Madeline Usher

Christopher Egan as Dorian Gray

Tom Degnan as Chris Van Helsing

Tamara Brown as Sergeant

HoJo Rose as Vlad Drakul(as Howard Rosenstein)

Lori Graham as Reporter

Matthew Kabwe as Fretful Father

Liana Montoro as Mother of sick child

Mélodie Simard as Girl at hospital

Laurean Adrian Parau as Airplane Passenger(uncredited)