Drew Barrymore as Chloe (voice)

Piper Perabo as Rachel Ashe Lynn

Andy García as Delgado (voice)

George Lopez as Papi (voice)

Paul Rodríguez as Chico (voice)

Plácido Domingo as Monte (voice)

Edward James Olmos as Diablo (voice)

Loretta Devine as Delta (voice)

Jamie Lee Curtis as Aunt Viv

Luis Guzmán as Chucho (voice)

Eddie 'Piolin' Sotelo as Rafa (voice)

Carlos Juvera as Tomás (voice)

Grey DeLisle as Mother Dog (voice)

Manolo Cardona as Sam Cortez

Leslie Mann as Bimini (uncredited)

Cheech Marin as Manuel (voice)

Michael Urie as Sebastian (voice)

José María Yázpik as Vasquez

Maury Sterling as Rafferty

Jesús Ochoa as Officer Ramirez

Eugenio Derbez as Store Owner

Omar Leyva as Ranger

Naomy Romo as Ranger

Ali Hillis as Angela

Marguerite Moreau as Blair

Nick Zano as Bryan

Gina Gallego as Shelter Director

Alberto Reyes as Bellman

Brandon Keener as Waiter

Sal Lopez as Ring Announcer

Giovanna Acha Aleman as Museum Guide

Jack Plotnick as Dog Nanny

Randall England as Butler

James P. Bennett as Bull Fighter (uncredited)

Mary Paz Mata as Shaman Lady

Tomihuatzi Xelhuantzi as Museum Security Guard

Mayra Sérbulo as Poor Woman

Fernando Manzano as Desk Sergeant