Simon Baker as Roderick Blank

Winona Ryder as Death Nell / Gillian De Raisx (#101)

Julie Bowen as Fiona Wormwood (#29)

Leslie Bibb as Dr. Miranda Storm

Skyler James Sandak as Roderick Blank Jr.

Natassia Malthe as Bambi

Jessica Kiper as Precious / Carlotta Valdes (#30)

Candice Coke as Greta Samsa (#32)

Pollyanna McIntosh as Thumper (#64)

Christopher Stapleton as Terry Fenchel (#71)

Retta as Ethel Walters (#100)

Corinne Reilly as Lizzie

Amanda Walsh as Stewardess Kathleen

Robert Wisdom as Alpha

Tanc Sade as Beta

Patton Oswalt as Fred

Dash Mihok as Lester

Neil Flynn as Zack

Indira Varma as Devon Sever

Sophie Monk as Cynthia Rose (#31)

Cindy Pickett as Roderick's Mother

Winter Ave Zoli as Alexis De Large (#37)

Bryan Okes as Buzzkilling Bodyguard

Frances Fisher as Hope Hartlight (#80)

Zachary Gordon as Barbecue Brat

Nicole Bilderback as Dr. Mirabella Stone (#66)

Keram Malicki-Sánchez as Master Bitchslap

Siobhan Flynn as Esther Fenchel