Simon Baker as Roderick Blank

Winona Ryder as Death Nell / Gillian De Raisx (#101)

Leslie Bibb as Dr. Miranda Storm

Mindy Cohn as Trixie

Julie Bowen as Fiona Wormwood (#29)

Dash Mihok as Lester

Neil Flynn as Zack

Patton Oswalt as Fred

Frances Fisher as Hope Hartlight (#80)

Robert Wisdom as Alpha

Marshall Bell as Victor Rose III

Sophie Monk as Cynthia Rose (#31)

Tanc Sade as Beta

Natassia Malthe as Bambi (#63)

Pollyanna McIntosh as Thumper (#64)

Rob Benedict as Bow-Tie Bob

Jessica Kiper as Precious / Carlotta Valdes (#30)

Winter Ave Zoli as Alexis De Large (#37)

Cindy Pickett as Roderick's Mother

Candice Coke as Greta Samsa (#32)

Christopher Stapleton as Terry Fenchel (#71)

Retta as Ethel Walters (#100)

Corinne Reilly as Lizzie

Amanda Walsh as Stewardess Kathleen

Indira Varma as Devon Sever

Bryan Okes as Buzzkilling Bodyguard

Zachary Gordon as Barbecue Brat

Skyler James Sandak as Roderick Blank Jr.

Nicole Bilderback as Dr. Mirabella Stone (#66)

Keram Malicki-Sánchez as Master Bitchslap

Siobhan Flynn as Esther Fenchel

Bryan Ross as Bachelor Party Buddy (as Brian Ross)

Greg Travis as Vulgar Newsstand Vendor

David Magidoff as Video Store Geek

Buckley Norris as Club Owner (as Buckley Francis Norris)

Tarek Bishara as Malcolm the Bartender (as Thom Bishops)

William Caploe as Barista Bill

Patrick Leo Holland as Wonderful Waiter

Ryan Cutrona as Officer Krupke

Cean Okada as Edwina Massey (#67)

Lauren Michelle Hill as Amberette

David Bortolucci as Agent

Annie Kehoe as Death Nell Wannabee

Kacie Borrowman as Vixen Blitzen (#69)

Elisha Skorman as Helena Hartford (uncredited)