Henry Winkler as Chuck Lumley

Michael Keaton as Bill Blazejowski

Shelley Long as Belinda Keaton

Gina Hecht as Charlotte Koogle

Pat Corley as Edward Koogle

Bobby Di Cicco as Leonard

Nita Talbot as Vivian

Basil Hoffman as Drollhauser

Tim Rossovich as Luke

Clint Howard as Jefferey

Joe Spinell as Manetti

Cheryl Carter as Tanya

Becky Gonzalez as Lupe

Corki Grazer as Sylvia

Jaid Barrymore as Joyce

Ava Lazar as Sharon

Robbin Young as Nancy

Ola Ray as Dawn

Cassandra Gava as J.J.

Mimi Lieber as Linda

Ashley Cox as Jenny Lynn

Elizabeth Carder as Dolores

Dawn Dunlap as Maxine

Jeanne Mori as Marsha

K.C. Winkler as Cheryl

Catherine Gilmour as Kim

Monique Gabrielle as Tessie

Jim Staahl as Red

Barbara Ann Grimes as Mrs. Koogle

Richard Belzer as Pig

Badja Djola as Cleon

Marc Flanagan as Steve

Beau Billingslea as Donny

Kevin Rodney Sullivan as Tyrone

Grand L. Bush as Mustafa

Julius LeFlore as Franklin

Floyd Levine as Sal Carboni

Reid Cruickshanks as Sgt. Averbach

Charles Fleischer as Prisoner

Tom Mahoney as Judge

Vincent Schiavelli as Carl

Jack Perkins as Tuttle

James Ritz as Morgue Worker

John Boyle as Leopard Boy

Brett Baxter Clark as Paradise Doorman

Paul S. Kaufman as Paradise Patron

Joy Michael Vogelbacher as Jacuzzi Girl

Hugo Napier as Blind Man

Tom Candela as Sailor #1

Eddie Gattalin as Sailor #2

Horace Long as Turkey Man

Angelo Vignari as Barber

Kevin Costner as Frat Boy #1

Russell Forte as Frat Boy #3

Jim Greenleaf as Frat Boy #4

Jason FitzGerald as Frat Boy #5

Jeremy Lawrence as Frat Boy #6

Shannen Doherty as Bluebird

Cheryl Howard as Girl Kissing Boyfriend in Front of Apartment (uncredited)

Ron Howard as Annoying Sax Player (uncredited)

Michael Pataki as Courtroom Mooner (uncredited)