Larry the Cable Guy as Mater (voice)

Keith Ferguson as Lightning McQueen (voice)

Jess Harnell as Captain Collision (voice)

Jan Rabson as I-Screamer (voice)

Simon Petrie as Rasta Carian (voice)

James Rankin as Dr. Feel Bad (voice)

Danny Mann as Referee Pitty (voice)

Frank Welker as Dr. Frankenwagon's Monster (voice)

Lance Henriksen as Paddy O'Concrete (voice)

Lindsey Collins as Mia (voice)

Elissa Knight as Tia (voice)

Daniel Gerson as Tormentor's Biggest Fan (voice)

Guido Quaroni as Guido (voice)

George Carlin as Filmore (voice)

Gord Robertson as MTW Announcer #1 (voice)

Neil Crone as MTW Announcer #2 (voice)

Lori Alan as Additional Voice Talent (voice)

Paul Eiding as Additional Voice Talent (voice)

Laraine Newman as Additional Voice Talent (voice)

Steve Purcell as Additional Voice Talent (voice)

Bob Scott as Additional Voice Talent (voice)

John Cygan as Additional Voice Talent (voice)

Mickie McGowan as Additional Voice Talent (voice)

Jack Angel as Additional Voice Talent (voice)