Gérard Depardieu as Christopher Columbus

Armand Assante as Sanchez

Sigourney Weaver as Queen Isabella

Loren Dean as Older Fernando

Ángela Molina as Beatrix

Fernando Rey as Marchena

Michael Wincott as Adrian de Moxica

Kevin Dunn as Captain Mendez

Tchéky Karyo as Martín Alonso Pinzón

Frank Langella as Santangel

Mark Margolis as Bobadilla

Arnold Vosloo as Guevara

Steven Waddington as Bartolome

Fernando Guillén Cuervo as Giacomo

Juan Diego Botto as Diego

Fernando García Rimada as King Ferdinand

Albert Vidal as Hernando de Talavera

José Luis Ferrer as Alonso de Bolaños

Jack Taylor as Vicuna

Billy L. Sullivan as Ten-Year-Old Fernando

John Heffernan as Brother Buyl