Brian Tochi as Leonardo (voice)

Josh Pais as Raphael (voice) / Passenger In Cab

Corey Feldman as Donatello (voice)

Robbie Rist as Michaelangelo (voice)

Judith Hoag as April O'Neil

Elias Koteas as Casey Jones

Kevin Clash as Splinter (voice)

David McCharen as The Shredder / Oroku Saki (voice)

David Forman as Leonardo / Gang Member

Martin P. Robinson as Leonardo

David Greenaway as Raphael

Kenn Scott as Raphael

Leif Tilden as Donatello / Foot Messenger

David Rudman as Donatello

Ernie Reyes Jr. as Donatello

Reggie Barnes as Donatello

Michelan Sisti as Michaelangelo / Pizza Man

Mark Wilson as Michaelangelo

Rickey Boyd as Splinter

Robert Tygner as Splinter

James Saito as The Shredder / Oroko Saki

Toshishiro Obata as Tatsu

Michael McConnohie as Tatsu (voice)

Michael Turney as Danny Pennington

Jay Patterson as Charles Pennington

Raymond Serra as Chief Sterns

Sam Rockwell as Head Thug

Kenn Scott as Talkative Foot #2

Kevin Eastman as Citizen (uncredited)

Skeet Ulrich as Thug (uncredited)

Scott Wolf as Thug (uncredited)

Paul Beahm as Foot Soldier (uncredited)

Curtis Bush as Foot Soldier