Michelle Pfeiffer as Rosie

Paul Rudd as Adam Perl

Saoirse Ronan as Izzie Mensforth

Tracey Ullman as Mother Nature

Stacey Dash as Brianna Minx

Fred Willard as Marty

Jon Lovitz as Nathan Mensforth

Sarah Alexander as Jeannie

Yasmin Paige as Melanie

Graham Norton as Taylor

David Mitchell as David - Writer

O-T Fagbenle as Sean Jamal Knight

Rory Copus as Dylan

Steve Pemberton as Censor

Henry Winkler as Self

Twink Caplan as Sissy

Ashley Lloyd as Zak

Wallace Shawn as Izzie's Teacher

Mackenzie Crook as Producer

Peter Polycarpou as 2nd Producer

Olivia Colman as Hairdresser

Archie Panjabi as Casting Girl

Ed Byrne as Delivery Boy

Chike Chan as Allergy Actor

Troy Gentile as Fighting Boy

Sally Kellerman as Self

Phil Cornwell as Cameraman

Iddo Goldberg as Director

Noah Lee Margetts as Monty

Jonathan Ryland as Prop Guy

Simon Kunz as Intruder

Victoria Chalaya as Nathan's Wife

Doña Croll as Marty's Secretary

Cassandra Bell as Pretty Waitress

Sam Fusaro as Bouncer

Jennifer Sims as Parent 2

Joe Montana as Very Large Guy

Melanie Martin as Sean's Wife (uncredited)

Wallace Shawn as Math Teacher (uncredited)

Kya Garwood as You go girl crew (uncredited)

Erin Gavin as Dancer (uncredited)

David Cassidy as Self (archive footage) (uncredited)

Richard Nixon as Self (archive footage) (uncredited)

Benito Mussolini as Self (archive footage) (uncredited)

Rene Costa as Diner (uncredited)

Ronan Summers as Staff Writer (uncredited)