Macaulay Culkin as Richard Tyler

Christopher Lloyd as Mr. Dewey

Whoopi Goldberg as Fantasy (voice)

Patrick Stewart as Adventure (voice)

Frank Welker as Horror (voice)

Leonard Nimoy as Dr. Jekyll / Mr. Hyde (voice)

Ed Begley Jr. as Alan Tyler

Mel Harris as Claire Tyler

B.J. Ward as Queen of Hearts (voice)

George Hearn as Captain Ahab (voice)

Ed Gilbert as George Merry (voice)

Phil Hartman as Tom Morgan (voice)

Jim Cummings as Long John Silver (voice)

Dorian Harewood as Jamaican Pirates (voice)

Robert Picardo as Pirate (voice)

Richard Erdman as Pirate (voice)

Fernando Escandon as Pirate (voice)

Canan J. Howell as Neighborhood Kid

Alexis Kirschner as Neighborhood Kid

Jessica Kirschner as Neighborhood Kid

Guy Mansker as Neighborhood Kid

Brandon S. McKay as Neighborhood Kid