Robin Williams as Henry Altmann

Mila Kunis as Dr. Sharon Gill

Peter Dinklage as Aaron Altmann

Melissa Leo as Bette Altmann

Hamish Linklater as Tommy Altmann

Sutton Foster as Adela

James Earl Jones as Ruben

Richard Kind as Bix

Daniel Raymont as Ulugbek

Chris Gethard as Dr. Jordan Reed

Jerry Adler as Cooper

Isiah Whitlock, Jr. as Yates

Bob Dishy as Frank

Da'Vine Joy Randolph as Nurse Rowan

Jeremie Harris as Leon

Lee Garlington as Gummy

Roy Milton Davis as Buster

Olga Merediz as Jane

Hank Chen as Damien

Rock Kohli as Gurjot

Kirk Taylor as Cop

Sunah Bilsted as Elevator Mother

Len Murach as Boat Captain

Noah Radcliffe as Tommy (10 Years Old)

Sawyer Ever as Tommy (5 Years Old)

Louis C.K. as Dr. Fielding

Adam Chernick as Peter (7 Years Old)

Zariah Singletary as Flower Girl

Chris Skeries as Pedestrian

Tucker Brown as Paul (Elevator Kid)