Ralph Macchio as Eugene Martone

Joe Seneca as Willie Brown

Jami Gertz as Frances

Joe Morton as Scratch's Assistant

Robert Judd as Scratch

Steve Vai as Jack Butler

Tim Russ as Robert Johnson

Dennis Lipscomb as Lloyd

Harry Carey, Jr. as Bartender

Wally Taylor as O.Z.

Allan Arbus as Dr. Santis

Edward Walsh as Harley Terhune

John Hancock as Sheriff Tilford

Allan Graf as Alvin

Al Fann as Pawnbroker

Guy Killum as Willie at 17

Gretchen Palmer as Beautiful Girl / Dancer

Tom Donaldson as John McGraw

Akosua Busia as Woman at Boardinghouse

Royce Wallace as Hotel Proprietor

J.W. Smith as Man at Auto Wrecking Yard

Diana Bellamy as Hospital Supervisor

Karen Huie as Nurse

Robin Townsend as Nurse

Jeanne Kiely as Nurse

Winifred Freedman as Nurse

Dolores Aguanno as Nurse

Debra Laws as Nurse

Diane Robin as Nurse

Leslie Morris as Bus Station Clerk

Gloria Delaney as Jookhouse Woman

Jo Marie Payton as Jookhouse Woman

Angela Robinson Witherspoon as Jookhouse Woman

Deborra Hampton as Jookhouse Woman

Le Van Hawkins as Jookhouse Man

Jason Ross as Jookhouse Man

Natasha Peacock as Young Girl at Crossroads

Agnes Narciso as Miss Narciso

Frank Frost as Jookhouse Musician - Harmonica / Vocalist

John Price as Jookhouse Musician - Drums

Otis Taylor as Jookhouse Musician - Lead Guitar

Richard 'Shubby' Holmes as Jookhouse Musician - Bass Guitar

Terry L. Evans as Jookhouse Musician - Keyboard

Bobby A. King as Guitar Duel Sequence Singer

Sam King as Guitar Duel Sequence Singer

Arnold McCuller as Guitar Duel Sequence Singer

Willie J. Greene Jr. as Guitar Duel Sequence Singer