María Félix as Doña Bárbara

Julián Soler as Santos Luzardo

María Elena Marqués as Marisela Barquero

Andrés Soler as Lorenzo Barquero

Charles Rooner as Don Guillermo

Agustín Isunza as Juan Primito

Miguel Inclán as Melquiades

Eduardo Arozamena as Melesio Sandoval

Antonio R. Frausto as Antonio Sandoval

Pedro Galindo as Nieves

Paco Astol as Mujiquita

Arturo Soto Rangel as Coronel Pernalete

Manuel Dondé as Carmelito López

Felipe Montoya as Balbino Paiba

Luis Jiménez Morán as Pajarote

Alfonso Bedoya as Peasant

Roberto Cañedo as Extra (uncredited)