Rupert Everett as Sherlock Holmes

Ian Hart as Dr. Watson

Nicholas Palliser as Dr. Dunwoody

Neil Dudgeon as Lestrade

Anne Carroll as Mrs Hudson

Tamsin Egerton as Miranda Helhoughton

Perdita Weeks as Roberta Massingham

Michael Fassbender as Charles Allen

Helen McCrory as Mrs. Vandeleur

Julian Wadham as Hugo Massingham

Guy Henry as Mr. Bilney

Jennifer Moule as Georgina Massingham

Eleanor David as Mary Pentney

John Cunningham as Bates

Jonathan Hyde as George Pentney

Gina Beck as Maid

Rachel Hurd-Wood as Imogen Helhoughton

Penny Downie as Judith Massingham

Jonathan Emmett as Policeman

Stewart Bevan as Proprietor