Matthew McConaughey as Cooper

Anne Hathaway as Brand

Michael Caine as Professor Brand

Jessica Chastain as Murph

Casey Affleck as Tom

Wes Bentley as Doyle

Topher Grace as Getty

Mackenzie Foy as Murph (10 Yrs.)

Ellen Burstyn as Murph (older)

John Lithgow as Donald

Bill Irwin as TARS (voice)

David Gyasi as Romilly

Timothée Chalamet as Tom (15 Yrs.)

Matt Damon as Mann

Josh Stewart as CASE (voice)

Leah Cairns as Lois

Liam Dickinson as Coop

Francis X. McCarthy as Boots

William Devane as Williams

Andrew Borba as Smith

Elyes Gabel as Administrator

David Oyelowo as School Principal

Collette Wolfe as Ms. Hanley

Jeff Hephner as Doctor

Russ Fega as Crew Chief

Lena Georgas as Nurse Practitioner

Brooke Smith as Nurse

Flora Nolan as Girl on Truck

Griffen Fraser as Boy on Truck

Kristian Van der Heyden as Scientist (uncredited)

William Patrick Brown as NASA Employee (uncredited)

Benjamin Hardy as NASA Scientist (uncredited)

Joseph Oliveira as Astronaut (uncredited)

Alexander Michael Helisek as Construction Boss (uncredited)