Johnny Depp as Dr. Will Caster

Rebecca Hall as Evelyn Caster

Paul Bettany as Max Waters

Cillian Murphy as Agent Donald Buchanan

Kate Mara as Bree

Cole Hauser as Colonel Stevens

Morgan Freeman as Joseph Tagger

Clifton Collins Jr. as Martin

Cory Hardrict as Joel Edmund

Falk Hentschel as Bob

Josh Stewart as Paul

Luce Rains as Roger

Fernando Chien as Heng

Steven Liu as Chiu

Xander Berkeley as Dr. Thomas Casey

Lukas Haas as James Thomas

Wallace Langham as Dr. Strauss

James Burnett as Meth Head #1

Sam Quinn as Meth Head #2

Sam Webb as Red Hooded Teenager

Chris Gartin as Tech Conference Coordinator

Olivia Taylor Dudley as Groupie

Abe Bueno-Jallad as RIFT Hacker

Lauren Sivan as Reporter

Laramie Cooley as BDC Greeter

Nancy Jeris as BDC Servant

Colin Jones as FBI Agent

Dylan Kenin as FBI Agent

Chad Brummett as Solar Field Worker

Antonio Del Prete as Will In Hybrid

Jon Kristian Moore as Will In Hybrid

John Trejo as Special Forces on Roof

Darren P. Leis as Medical Lab Tech

Donna Brown as RIFT Surgeon

Richard Daniel Williams as RIFT Surgeon

Zack Carpenter as RIFT Medical Tech

Christina Lancellotti as RIFT Medical Tech

Kristen DeVore Rakes as MIT Programmer

Seth Adkins as Miserable Student

Jaime Powers as Hybrid Townsman (uncredited)

Lyn Quinn as Tech Conference Attendee (uncredited)

Kendra Tuthill as Townswoman (uncredited)

Darrick Hurst as Berkeley Student (uncredited)

Dennis Keiffer as Hybrid Soldier (uncredited)

Elon Musk as Elon Musk (uncredited)

Fergaledgar as John Mccarthy (uncredited)

Tureygua Inaru as RIFT Member