Rob Corddry as Jack

Leslie Bibb as Vanessa

Keegan-Michael Key as F'resnel

Paul Scheer as Ron

Rob Huebel as Mickey

Thomas Lennon as Father Padrigo

Michael Ian Black as Dr. Marshall

Brittney Alger as Italian Nurse

Dave Holmes as Rental Car Guy

Alex Berg as Mrs. Nussbaum / Cheerful Guy

Riki Lindhome as Marjorie

David Pasquesi as Cardinal Vicente

David Wain as Dr. Marsden

Kumail Nanjiani as Cable Guy

Robert Ben Garant as Father Sebastian

Cathy Shim as Catholic School Girl

Jenny Robertson as Mail Carrier