Benicio del Toro as Jimmy Picard

Mathieu Amalric as Georges Devereux

Gina McKee as Madeleine

Larry Pine as Dr. Karl Menninger

Joseph Cross as Dr. Holt

Ilya Baskin as Dr. Jokl

Gary Farmer as Jack

Michelle Thrush as Gayle Picard

Misty Upham as Jane

Jennifer Podemski as Doll

Michael Greyeyes as Allan

A Martinez as Bear Willie Claw

Lise Lacasse as Miss Wharton

Linda Boston as Head of Admissions

Barton Bund as Radiologist

Loren Bass as Neurologist

Dennis North as Dr. Braatoy

David Lawrence Regal as Biologist

Hugh Maguire as Opthalmologist

Stephen Bridgewater as Officer

Danny Mooney as Eric McMurphy

Taras Los as Desmond

Jim Ochs as Bartender

Anton Bassey as Sam

Inga R. Wilson as Alma

Matthew Géczy as Sergeant Major Bob

Scott Thrun as Sergeant

Julie Sifuentes Etheridge as Avy Spring, Sexy Nurse

Dakota Padgett as Jimmy Child

Samantha Reed as Older Sister

Amy Grant as Gayle 19 Years Old

Greg Johnson as Judge

Michael Murphy as Jimmy's Lawyer

Shayanna Campbell as Mary-Lou 11 Years Old

Lily Gladstone as Sunshine First Raise

Randi Kennerly as Mary-Lou 14 Years Old

Tom Mahard as Janitor

LaDonna Graham as Teller

John Dickerson as Patient

Jesse Arehart-Jacobs as Puppeteer 1

Andrew Bruce Mitchell II as Puppeteer 2