António Vilar as Cristóbal Colón

Amparo Rivelles as Reina Isabel la Católica

María Martín as Beatriz

José Suárez as Rey Fernando el Católico

Virgílio Teixeira as Pedro de Arana

Manuel Luna as Isaac

Eduardo Fajardo as Gastón

Jesús Tordesillas as Fray Juan Pérez

Ana María Custodio as Madre de Beatriz

José Marco Davó as Martín Alonso Pinzón

Ernesto Vilches as Cabrero

Alberto Romea as Cardenal Mendoza

Nicolás D. Perchicot as Fray Antonio de Marchena

Fernando Sancho as Pedro Salcedo

Francisco Pierrá as Miembro de la junta

Arturo Marín as Pedro Vázquez de la Frontera

Antonio Casas as Juan de la Cosa

Faustino Bretaño as Mensajero que se arrodilla

José Jaspe as Marinero

Vicente Soler as Conde de Quintanilla

Carlos Díaz de Mendoza as Miembro de la junta

Alfonso Candel as

Joaquín Puyol as

Miguel Pastor as Pregonero

Félix Dafauce as Villamarín

Francisco Hernández as

José Sepúlveda as Cristóbal Sarniento

Francisco Arenzana as Francisco Arias

Ramón Elías as

Rafael Arcos as Mensajero del Rey

Francisco Bernal as Posadero

Luis Torrecilla as

Jacinto San Emeterio as Gonzalo de Córdoba

Domingo Rivas as Duque de Medina

Gary Land as

Antonio Almorós as Vicente Yáñez Pinzón

Benito Cobeña as

Manrique Gil as

Pablo Álvarez Rubio as

Teófilo Palou as Secretario de la Corona

Rafael Calvo Revilla as Secretario de la Corona

Manuel Aguilera as Secretario de la Corona

César Guzmán as

Luis Rivera as

Carmen Capdepont as

José María Labernié as

Francisco Maroto as

Luis Fernández as

José Riesgo as Miembro del consejo

Luisa Díaz de Velasco as

Rafael Cortés as

Pedro Conejero as

Francisco Rodríguez as