Gael García Bernal as Ernesto "Che" Guevara de la Serna

Rodrigo de la Serna as Alberto Granado

Mercedes Morán as Celia de la Serna

Mía Maestro as Chichina Ferreyra

Jean Pierre Noher as Ernesto Guevara Lynch

Lucas Oro as Roberto Guevara

Marina Glezer as Celita Guevara

Sofia Bertolotto as Ana María Guevara

Franco Solazzi as Juan Martín Guevara

Ricardo Díaz Mourelle as Uncle Jorge

Gustavo Bueno as Dr. Hugo Pesce

Antonella Costa as Silvia

Natalia Lobo as La Negra (Argentina)

Erto Pantoja as Mechanic

Cristián Chaparro as Luna

Cristian Arancibia as Tulio

Gabriela Aguilera as Piedad

Constanza B. Majluf as Chilean Sister

Víctor Hugo Ogaz as Waiter

Fernando Farías as Chief Firefighter

Pablo Macaya as Moncho

Vilma Verdejo as Miner's Wife

Jaime Azócar as Mine Foreman