Jeff Bridges as Dr. Mark Powell

Kevin Spacey as Prot

Mary McCormack as Rachel Powell

Alfre Woodard as Claudia Villars

Ajay Naidu as Dr. Chakaraborty

Vincent Laresca as Navarro

Kimberly Scott as Joyce Trexler

Conchata Ferrell as Betty McAllister

Saul Williams as Ernie

Peter Gerety as Sal

David Patrick Kelly as Howie

Melanee Murray as Bess

Celia Weston as Mrs. Archer

Brian Howe as Steve Becker

Greg Lewis as Dominic McAllister

John Toles-Bey as Russell

Mark Christopher Lawrence as Simms

Mary Mara as Abby

Brandon de Paul as Josh - Age 10

Tess McCarthy as Natalie Powell - Age 6

Natasha Dorfhuber as Gabby Powell - Age 9

Aaron Paul as Michael Powell - Age 21

William Lucking as Sheriff

Zofia Borucka as Woman on Train

Curt Clendenin as Hospital Patient (uncredited)

Frank Collison as Screaming Man (uncredited)

Moet Meira as Jennifer (uncredited)

Peter Maloney as Duncan Flynn

Lance E. Nichols as David Patel

Erik LaRay Harvey as Security Guard

Paulo Pascoal as Thief (Uncredited)

Tracy Vilar as Maria