Jeff Bridges as Dr. Mark Powell

Kevin Spacey as Prot

Mary McCormack as Rachel Powell

Alfre Woodard as Claudia Villars

David Patrick Kelly as Howie

Saul Williams as Ernie

Peter Gerety as Sal

Celia Weston as Mrs. Archer

Ajay Naidu as Dr. Chakaraborty

Tracy Vilar as Maria

Melanee Murray as Bess

John Toles-Bey as Russell

Kimberly Scott as Joyce Trexler

Conchata Ferrell as Betty McAllister

Vincent Laresca as Navarro

Mark Christopher Lawrence as Simms

Brian Howe as Steve Becker

Mary Mara as Abby

Tess McCarthy as Natalie Powell - Age 6

Natasha Dorfhuber as Gabby Powell - Age 9

Brandon de Paul as Josh - Age 10

Aaron Paul as Michael Powell - Age 21

William Lucking as Sheriff

Kelly Connell as Walter Fleen

Peter Maloney as Duncan Flynn

Lance E. Nichols as David Patel

Paul Linke as Stuart Hessler

Christopher Jason Brown as Danny Trexler

Greg Lewis as Dominic McAllister

Clarke Peters as Homeless Veteran

Olga Merediz as Transit Officer

Joe Holt as Transit Officer

Lola Pashalinski as Russian Woman

Kateri Walker as Sara Porter

Katya Abelski as Rebecca Porter

Scott Lincoln as Walker

Clebert Ford as Homeless Man

Norman Alden as Babbling Man

Rawle D. Lewis as Security Guard

Erik LaRay Harvey as Security Guard

Zofia Borucka as Woman on Train

Tony Rhune as Thug

Vince Cupone as Thug

Anne Carroll as Ward Patient

Lisa Cohen as Ward Patient

Clete Francis as Ward Patient

Valerie Giocondo as Ward Patient

Pat Jankiewicz as Ward Patient

Joseph Steven as Ward Patient

Coco Leigh as Ward Patient

Rafael Real as Ward Patient

Julie Sands as Ward Patient

Gene Smith as Ward Patient

Curt Clendenin as Hospital Patient (uncredited)

Frank Collison as Screaming Man (uncredited)

Moet Meira as Jennifer (uncredited)

Paulo Pascoal as Thief (Uncredited)

Mark Alkofer as Subway Commuter (uncredited)

Ted Hollis as Ward Doctor (uncredited)

Randy Springer as Lab Tech (uncredited)