Gary Sinise as Harry S Truman

Diana Scarwid as Bess Truman

Richard Dysart as Henry L. Stimson

Colm Feore as Charlie Ross

James Gammon as Sam Rayburn

Tony Goldwyn as Clark Clifford

Pat Hingle as Boss Tom Pendergast

Harris Yulin as Gen. George C. Marshall

Leo Burmester as Frank Vassar

Amelia Campbell as Margaret Truman

Virginia Capers as Elizabeth Moore

John Finn as Bob Hannagan

Zeljko Ivanek as Eddie Jacobsen

David Lansbury as Lt. Jim Pendergast

Remak Ramsay as Dean Acheson

Marian Seldes as Eleanor Roosevelt

Lois Smith as Madge Wallace Gates

Daniel von Bargen as General MacArthur

Winston Churchill as Self (archive footage) (uncredited)

Lee Richardson as Franklin D. Roosevelt (uncredited)

Harry Gibbs as Vice-President Garner

Jessica Drake as Woman Reporter

Addison Myers as Operator

Michael Murphy as Dinner Speaker (uncredited)

Jason Ray as Soldier (Uncredited)

Nora Denney as Mama Truman