Matthew Perry as Hudson Milbank

Lynn Collins as Sara Harrison

Kevin Pollak as Tom

Bob Gunton as Dr. Townshend

Helen Shaver as Audrey Milbank

William B. Davis as Peter Milbank

Mary Steenburgen as Dr. Blaine

Ben Immanuel as Stan Milbank

Noah Dalton Danby as Tim

Monique Ganderton as Debra

Mark Acheson as Homeless Guy

Patricia Harras as Dr. Simon

Brad Ganes as John

Ingrid Torrance as Female Psychologist

Brian George as Dr. Richmond

Graham Kosakoski as Big 5 Salesman

Jovanna Huguet as Cute Nervous Girl

Burkely Duffield as Young Hudson

Suzanne Serwatuk as Assistant

Angela Besharah as Receptionist

Jerry Rector as BMW Salesman

Benjamin Ayres as Brad

Donny Lucas as ER Doctor

Barry W. Levy as Executive

Rachel Hayward as Spinning Instructor

Reg Tupper as Big Executive

Melanie Yeats as Executive Assistant

Keegan Connor Tracy as Mt. Sinai Nurse

Tony Alcantar as Mt. Sinai Researcher

Peter Hall as Neurologist

Lyle St. Goddard as Sky Cap

Linden Banks as Pharmacist

Brett Delaney as Police Officer

Caroline Haisler as Real Estate Agent

Mark Gash as Sanatorium Doctor

Julia Benson as Sara’s Girlfriend

Beverley Breuer as Secretary

Holly Eglington as Stripper

Michael Adamthwaite as Thug

Darcy Michael as Videos Store Clerk

Donna Yamamoto as Cashier

Erica Van Briel as Girl in the Rain

Nancy J. Lilley as Irate Lady