Tobey Maguire as Homer Wells

Charlize Theron as Candy Kendall

Michael Caine as Dr. Wilbur Larch

Delroy Lindo as Arthur Rose

Paul Rudd as Lt. Wally Worthington

Jane Alexander as Nurse Edna

Kathy Baker as Nurse Angela

Erykah Badu as Rose Rose

Kieran Culkin as Buster

Kate Nelligan as Olive Worthington

Heavy D as Peaches

J.K. Simmons as Ray Kendall

Erik Per Sullivan as Fuzzy

Paz de la Huerta as Mary Agnes

K. Todd Freeman as Muddy

Evan Parke as Jack

Jimmy Flynn as Vernon

Lonnie Farmer as Hero

Spencer Diamond as Curly

Skye McCole Bartusiak as Hazel

Sean Andrew as Copperfield

John Albano as Steerforth

Claire Daly as Clara

Colin Irving as Major Winslow

Annie Corley as Carla

Patrick Donnelly as Adopting Father

Edie Schechter as Adopting Mother

Kasey Berry as 12yr. Old Girl

Mary Bogue as Big Dot

Victoria Stankiewicz as Debra

Christine Stevens as Florence

Earle C. Batchelder as Dr. Holtz

Norma Fine as Mrs. Goodhall

John Irving as Stationmaster

Eric Bruno Borgman as Flirting Soldier on Train (uncredited)

Kevin Chapman as Adopting Dad (uncredited)

John H. Tobin as Man on Train (uncredited)