Robert Downey Jr. as Steve Lopez

Jamie Foxx as Nathaniel Ayers

Catherine Keener as Mary Weston

Tom Hollander as Graham Claydon

Nelsan Ellis as David Carter

Michael Bunin as Adam Crane

LisaGay Hamilton as Jennifer Ayers

Rachael Harris as Leslie Bloom

Stephen Root as Curt Reynolds

Lorraine Toussaint as Flo Ayers

Jena Malone as Cheery Lab Tech

Octavia Spencer as Troubled Woman

Justin Martin as Young Nathaniel

Kokayi Ampah as Bernie Carpenter

Patrick Tatten as Paul Jr.

Susane Lee as Marisa

Marcos De Silvas as Mayor Villaigosa

Ilia Volok as Harry Barnoff

Mike Nowak as Julliard Conductor

David Jean Thomas as Angry Homeless Man

Lemon Andersen as Uncle Tommy

Kevin Michael Key as Homeless Transvestite

Moya Brady as Barely Dressed Woman

Orlando Ashley as LAMP Homeless Guy

Artel Great as Leon

J.J. Boone as Shouting Woman

Annie McKnight as LAMP Advocate

Bernadette Speakes as Homeless Lady

Anna Levin as Leeann

Steve Foster as Steve

Vivian George as Teresa

Kevin Cohen as KK

Courtney Andre as Courtney

Teri Hughes as Detroit

Linda Harris as Linda

Albert Olson as Bam Bam

Melissa Black as Melissa

Valarie Hudspeth as Mama Grouch

Darryl Black St. as Darryl

Kiana Parker as Kiana

Hazard Banner as Hazard

Russell Brown as Russell

Jacqueline Sue West as Jackie

Joyre Manuel as Ashley

Lorinda Hawkins as Singing Woman

Annette Valley as Annette

Patrick Kelly as Patrick

Quiana Farrow as Quiana

Tony Genaro as Globe Lobby Guard

Charlie Weirauch as Atheist

Wayne Lopez as Cop with Tents

Joe Hernandez-Kolski as EMT #1

Noel Gugliemi as Winston Street Cop

Paul Cruz as EMT #2

Wil Garret as Homeless Man

Halbert Hernandez as EMT #3

Alejandro Patiño as Construction Worker

Karole Selmon as Homeless Woman #1

Rob Nagle as Neil

Patricia Place as Cello Donor

Ralph Cole Jr. as Enraged Homeless Man

Gladys Khan as Reception Nurse

Palma Lawrence Reed as ER Nurse

Isabel Hubmann as Laid-off Employee

Bonita Jefferson as Homeless Woman #2

Eshana O'Neal as Winston Street Prostitute

Myia Hubbard as Young Jennifer Ayers

Iyanna Newborn as Miss Little John

Bronwyn Hardy as Beauty Shop Girl

Troy Blendell as News Editor

Nick Nervies as Jennifer's Son

Paul Norwood as Editor

Wally Lozano as Sign Spinner (uncredited)