Babe Ruth as Babe (as George Herman 'Babe' Ruth)

Ruth Taylor as Mildred Tobin

William Sheer as Harry Knight

Margaret Seddon as Babe's Mother

Frances Victory as Pigtails

James A. Marcus as Simon Tobin

Ralf Harolde as John Tobin (as Ralph Harolds)

Charles Byer as David Talmadge (as Charles Burt)

George Halpin as Doc Hedges / The Constable / Dog Catcher

William J. Gross as Eliar Lott

Walter Lawrence as Tony Marino

Ann Brody as Mrs. Tony Marino (as Anne Brodie)

Ricca Allen as Almira Worters

Sammy Blum as Jimbo Jones (as Sam Blum)

Ethel Kerwin as Kitty Wilson

Tom Cameron as Deacon Flack (as Thomas Cameron)

Charles J. Hunt as Reverend David Talmadge