Wentworth Miller as Michael Scofield

Sarah Wayne Callies as Sara Tancredi

Dominic Purcell as Lincoln Burrows

Jodi Lyn O'Keefe as Gretchen Morgan

Amaury Nolasco as Fernando Sucre

Robert Knepper as Theodore 'T-Bag' Bagwell

William Fichtner as Alex Mahone

Leon Russom as Jonathan Krantz

Amy Aquino as Warden Alice Simms

Lori Petty as Daddy

Kim Coates as Agent Richard Sullins

Barbara Eve Harris as FBI Agent Felicia Lang

Chris Bruno as Agent Todd Wheatley

David Starzyk as Blue Phillips

Aisha Hinds as Guard Cowler

Jeff Cahill as Snee

Dendrie Taylor as Blonde Guard

Damien Leake as Detective Marlin

Livia Treviño as Hucks

Alicia Lagano as Agatha

Dot-Marie Jones as Skittlez

Kathleen Quinlan as Christina Rose Scofield

Adrienne McQueen as Prison Guard (uncredited)

'Big' LeRoy Mobley as Hotel Security Guard (uncredited)