James Cagney as Tom Powers

Jean Harlow as Gwen Allen

Edward Woods as Matt Doyle

Joan Blondell as Mamie

Donald Cook as Mike Powers

Leslie Fenton as Samuel 'Nails' Nathan

Beryl Mercer as Ma Powers

Robert Emmett O'Connor as Paddy Ryan

Murray Kinnell as Putty Nose

Clark Burroughs as Dutch (uncredited)

Mae Clarke as Kitty (uncredited)

Frank Coghlan Jr. as Tom as a Boy (uncredited)

George Daly as Machine Gunner (uncredited)

Frankie Darro as Matt as a Boy (uncredited)

Snitz Edwards as Miller (uncredited)

Rita Flynn as Molly Doyle (uncredited)

Dorothy Gee as Nails' Girl (uncredited)

Douglas Gerrard as Assistant Tailor (uncredited)

Dorothy Gray as Little Girl (uncredited)

Ben Hendricks Jr. as 'Bugs' Moran as a Boy (uncredited)

Robert Homans as Officer Pat Burke (uncredited)

Eddie Kane as Joe - Headwaiter (uncredited)

Mia Marvin as Jane (uncredited)

Sam McDaniel as Headwaiter (uncredited)

Helen Parrish as Little Girl (uncredited)

Lee Phelps as Steve - Bartender (uncredited)

Russ Powell as Bartender (uncredited)

Purnell Pratt as Officer Powers (uncredited)

Nanci Price as Little Girl (uncredited)

Joe Sawyer as Pool Player (uncredited)

Landers Stevens as Doctor (uncredited)

William H. Strauss as Pawnbroker (uncredited)

Charles Sullivan as Mug (uncredited)

Lucille Ward as Mrs. Dalton (uncredited)

Adele Watson as Mrs. Doyle (uncredited)