Jessica Biel as Rose Johnny

Eddie Redmayne as Qwerty Doolittle

Forest Whitaker as Charlie

Ray Liotta as Jack Doheny

Patrick Swayze as Velvet Larry

Lisa Kudrow as Sally

Kris Kristofferson as Randall

Sanaa Lathan as Diana

Ravi Patel as Sanjay

Mandy June Turpin as Nurse Jenkins

Diana Prince as Stripper (uncredited)

Chandler Canterbury as Billy

Navid Negahban as Doctor Brooks

Billy Wirth as David

Don Swayze as Bouncher

Ben Hernandez Bray as Security

Joe Holt as Resident Doctor

L. Scott Caldwell as Nurse Gomez

Riki Lindhome as Nicole

Ana Berry as Female Host

Soledad Campos as Catholic Nun

Danvy Pham as Velvet Larry's Girl

Sala Baker as Thug #1

Alejandro Romero as Lexus

Jeffery A. Baker as Slim

Jesse Henecke as Loan Manager