Scott Wolf as Scamp (speaking) (voice)

Alyssa Milano as Angel (speaking) (voice)

Chazz Palminteri as Buster (speaking) (voice)

Jeff Bennett as Tramp / Jock / Trusty / Dogcatcher (voice)

Jodi Benson as Lady (voice)

Bill Fagerbakke as Mooch (voice)

Mickey Rooney as Sparky (voice)

Bronson Pinchot as Francois (voice)

Cathy Moriarty as Ruby (voice)

Mary Kay Bergman as Si (voice)

Debi Derryberry as Annette (voice)

Barbara Goodson as Darling (voice)

Nick Jameson as Jim Dear (voice)

Tress MacNeille as Aunt Sarah / Am (voice)

Rob Paulsen as Otis (voice)

Kath Soucie as Collette / Danielle (voice)

Frank Welker as Reggie (voice)

April Winchell as Mrs. Mahoney (voice)

Jim Cummings as Tony (voice)

Michael Gough as Joe (voice)

Jess Harnell as Buster (singing voice) (uncredited)

Andrew McDonough as Junior (voice)