Dave Foley as Marv / Psychiatrist / New guy / Raymond Hurdicure

Bruce McCulloch as Alice / Cisco / Grivo / Worm pill scientist / Cop #2 / Cancer boy / White-trash man

Kevin McDonald as Dr. Chris Cooper / Doreen / Chris' dad / Lacey

Mark McKinney as Simon / Don Roritor / Cabbie / Gunther / Cop #1 / Nina Bedford / Melanie / Drill sergeant / White-trash woman

Scott Thompson as Baxter / Mrs. Hurdicure / Wally Terzinsky / Malek / Big Stummies scientist / The Queen / Raj / Clemptor

Kathryn Greenwood as Ginny Hurdicure

Nicole de Boer as Cooper's Groupie

Krista Bridges as Cooper's Groupie

Christopher Redman as Wally Jr.

Sherry Hilliard as Coma Queen

Brendan Fraser as Placebo Patient

Janeane Garofalo as Woman at Party

Lindsay Leese as Scientist

Kirsten Johnson as Scientist

Jackie Harris Greenberg as Natalie

Erica Fairfield as Wally's Daughter

Andy Jones as Monkey Scientist