Carole Lombard as Jane Mason

James Stewart as John Horace Mason

Charles Coburn as Judge Joseph M. Doolittle

Lucile Watson as Mrs. Harriet Mason

Eddie Quillan as Conway

Alma Kruger as Sister Madeline

Irving Bacon as Newark Radio Operator (uncredited)

Raymond Bailey as Salt Lake City Hospital Chemist (uncredited)

Louise Beavers as Lily (uncredited)

Ward Bond as Jim Hatton (uncredited)

Donald Briggs as Mr. Carter (uncredited)

Harlan Briggs as Judge (uncredited)

Lane Chandler as Ranger on Telephone (uncredited)

Frederick Chapin as Younger Doolittle (uncredited)

Russ Clark as Omaha Radio Operator (uncredited)

Monte Collins as Juror (uncredited)

James Conaty as Co-Worker (uncredited)

Esther Dale as Annie (uncredited)

Harry Davenport as Dr. Healy (uncredited)

Edgar Dearing as Mounted Policeman (uncredited)

Harry Depp as Hutch (uncredited)

Robert Elliott as Airport Operations Manager (uncredited)

Fern Emmett as Farmer's Wife (uncredited)

Betty Farrington as Hospital Cashier (uncredited)

Mary Field as Johns Hopkins Technician (uncredited)

Ruth Gillette as Tipsy Blonde at New Year's Eve Party (uncredited)

Russell Hopton as Collins (uncredited)

Olin Howland as Farmer (uncredited)

Arthur Hoyt as Jury Foreman (uncredited)

Victor Kilian Jr. as Chicago Radio Operator (uncredited)

Tom London as Ranger (uncredited)

Ethel Marical as Nurse (uncredited)

Edwin Maxwell as Messerschmidt (uncredited)

Tom McGuire as Bailiff (uncredited)

James McNamara as Juror (uncredited)

Carlyle Moore Jr. as North Platte Radio Operator (uncredited)

Wilhelmina Morris as Nurse (uncredited)

Jack Mulhall as Rock Springs Radio Operator (uncredited)

Robert Emmett O'Connor as Harry (Elevator Starter) (uncredited)

Renee Orsell as Hilda (uncredited)

Garry Owen as Denver Radio Operator (uncredited)

John Picorri as Juror (uncredited)

Mickey Rentschler as Office Boy (uncredited)

Cyril Ring as Office Worker (uncredited)

Mildred Shay as John Horace Mason's Secretary (uncredited)

Ivan F. Simpson as Simon (uncredited)

Milburn Stone as Newark Official (uncredited)

Nella Walker as Dr. Langham's Nurse-Receptionist (uncredited)

Ruth Weston as Eunice Doolittle (uncredited)

Marjorie Wood as Nurse (uncredited)

Harry Worth as New York Hospital Chemist (uncredited)