Don Ameche as Henry Van Cleve

Gene Tierney as Martha Strabel Van Cleve

Charles Coburn as Hugo Van Cleve

Marjorie Main as Mrs. Strabel

Laird Cregar as His Excellency

Spring Byington as Bertha Van Cleve

Allyn Joslyn as Albert Van Cleve

Eugene Pallette as E.F. Strabel

Signe Hasso as Yvette ("Mademoiselle")

Louis Calhern as Randolph Van Cleve

Helene Reynolds as Peggy Nash

Aubrey Mather as James

Tod Andrews as Jack Van Cleve

Florence Bates as Mrs. Edna Craig (uncredited)

Scotty Beckett as Henry Van Cleve - Age 9 (uncredited)

Clara Blandick as Grandmother Van Cleve (uncredited)

Leonard Carey as Flogdell (uncredited)

James Conaty as Man in Park with Top Hat (uncredited)

Jack Deery as Party Guest (uncredited)

Claire Du Brey as Miss Ralston - Jack's Secretary (uncredited)

Jay Eaton as Book Store Clerk (uncredited)

James Flavin as Policeman (uncredited)

Bess Flowers as Party Guest (uncredited)

Gary Gray as Boy in Park (uncredited)

Alfred Hall as Albert's Father (uncredited)

Grayce Hampton as Albert's Mother (uncredited)

Marlene Mains as Mary - Age 9 (uncredited)

Trudy Marshall as Jane Van Cleve - Jack's Wife (uncredited)

Edwin Maxwell as Doctor (uncredited)

Michael McLean as Henry Van Cleve - as Baby (uncredited)

Doris Merrick as Nellie Brown - Registered Nurse (uncredited)

Harold Miller as Party Guest (uncredited)

Dickie Moore as Henry Van Cleve - Age 15 (uncredited)

Bert Moorhouse as Party Guest (uncredited)

Clarence Muse as Jasper (uncredited)

Monty O'Grady as Party Guest (uncredited)

Anne O'Neal as Day Nurse (uncredited)

Gerald Pierce as Elevator Operator (uncredited)

Nino Pipitone Jr. as Jack Van Cleve - as Child (uncredited)

June Preston as Jack Van Cleve daughter (age 13) (uncredited)

Maureen Roden-Ryan as Bediliah - Nurse in Park (uncredited)

Anita Sharp-Bolster as Mrs. Cooper-Cooper (uncredited)

Gerald Oliver Smith as Smith - Van Cleve's Second Butler (uncredited)