Drew Barrymore as Holly Gooding

George Newbern as Patrick Highsmith

Dennis Christopher as Doctor Heller

Leslie Hope as Elizabeth

Sally Kellerman as Sister Jan

George Maharis as Mike Wallace

Peter Dobson as Rob

Carl Bressler as Larry Spaulding

Dan Shor as Stanley White

Jaid Barrymore as Mrs. Gooding

Stanley DeSantis as Richard Wolf

Sean Whalen as Gas Man

Thomas Bosack as Holly's Father

Sarina C. Grant as Detective Pouget

John Cardone as Handcuffed Man

Irene Olga López as Night Nurse

Scott Lawrence as Male Nurse

Danny Trejo as Hard Hat

Karen Leigh Hopkins as Psycho-slut #1

Sara Hickman as Psycho-slut #2

Luana Anders as Ginger

Steven J. Oliver as Man in Van

Kathy Grable as Waitress

Don Perry as Priest

Lee Magnuson as Homeless Man

Mike Watters as Officer Mike Watters

Mike Webb as Officer Webb

Sandra Lee Williams as Nurse Jenkins

Edward D. Murphy as Doorman